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Ozleyen, A., Duran, G. N., Donmez, S., Ozbil, M., Doveston, R. G., & Tumer, T. B. (2025).
Identification and inhibition of PIN1-NRF2 protein–protein interactions through computational and biophysical approaches.
Scientific Reports, 15(1), 8907.
https://doi.org/10.1038/s41598-025-89342-0


Ozturk, N., Yay, C., Cinar, Z. Ö., Atalay, H. N., Guneser, O., Hosoglu, M. I., & Tumer, T. B. (2025).

Optimizations related to the use of Lactobacillus helveticus, Kluyveromyces marxianus in monoculture, and co-culture for production of Spirulina-based fermented products.
Algal Research,
103, 103948.


Yilmaz, Y. B., Güngör, T., Dönmez, S., Atalay, H. N., Siyah, P., Durdağı, S., Ay, M., & Tumer, T. B. (2025).
Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H₂S release profiles.
RSC Medicinal Chemistry.
https://doi.org/10.1039/D4MD00495G


Dönmez, S., Lapinskaite, R., Atalay, H. N., Tokay, E., Kockar, F., Rycek, L., Özbil, M., & Tumer, T. B. (2024).
Selagibenzophenone B and its derivatives: SelB-1, a dual topoisomerase I/II inhibitor identified through in vitro and in silico analyses.
ACS Bio & Med Chem Au,
4(4), 178-189. https://doi.org/10.1021/acsbiomedchemau.4c00027


Yay, C., Cinar, Z. O., Donmez, S., Tumer, T. B., Guneser, O., & Hosoglu, M. I. (2024).

Optimizing bioreactor conditions for Spirulina fermentation by Lactobacillus helveticus and Kluyveromyces marxianus: Impact on chemical & bioactive properties.
Bioresource technology,
 403, 130832. https://doi.org/10.1016/j.biortech.2024.130832
 

Antika, G., Cinar, Z. Ö., Dönmez, S., Seçen, E., Özbil, M., Prandi, C., & Tumer, T. B. (2024).
Effects of Strigolactones on NLRP3 Activation, Nitrosative Stress, and Antioxidant Mox Phenotype: In Vitro and In Silico Evidence.
ACS bio & med chem Au
, 4(3), 131–136. https://doi.org/10.1021/acsbiomedchemau.3c00063

 
  

Nallappan, S., Lapinskaite, R., Hájíček, J., Kunák, D., Čambal, P., Nečas, D., Císařová, I., Atalay, H. N., Tumer, T. B., Tarábek, J., Schwarzová-Pecková, K., & Rycek, L. (2024).
The Biomimetic Synthesis of Polyarylated Fluorenes, Relevant to Selaginellaceae Polyphenols, Leading to the Spontaneous Formation of Stable Radicals. 
ChemPlusChem,
 89(4), e202300410. https://doi.org/10.1002/cplu.202300410


Bukowska, B., Duchnowicz, P., Tumer, T. B., Michałowicz, J., & Krokosz, A. (2023).
Precarcinogens in food – Mechanism of action, formation of DNA adducts and preventive measures.
Food Control,
152, 109884. https://doi.org/10.1016/j.foodcont.2023.109884

 
Güngör, T., Atalay, H. N., Yilmaz, Y. B., Tumer, T. B., & Ay, M. (2023).
Synthesis of new imine-/amine-bearing imidazo[1,2-a]pyrimidine derivatives and screening of their cytotoxic activity.
Turkish journal of chemistry,
 47(5), 1064–1074. https://doi.org/10.55730/1300-0527.3594


Ozleyen, A., Yilmaz, Y. B., Donmez, S., Atalay, H. N., Antika, G., & Tumer, T. B. (2023).
Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention.
Journal of cancer research and clinical oncology,
 149(5), 2095–2113. https://doi.org/10.1007/s00432-022-04187-8


Lapinskaite, R., Atalay, H. N., Malatinec, Š., Donmez, S., Cinar, Z. O., Schwarz, P. F., Perhal, A. F., Císařová, I., Labanauskas, L., Karpiński, T. M., Dirsch, V. M., Tumer, T. B., & Rycek, L. (2023).
Synthesis of Selagibenzophenone A and its derivatives for evaluation of their antiproliferative, RORγ inverse agonistic, and antimicrobial effect.
ChemistrySelect,
8(7), e202204816. https://doi.org/10.1002/slct.202204816
 

Pyrzanowska-Banasiak, A., Boyunegmez Tumer, T., Bukowska, B., & Krokosz, A. (2023).
A multifaceted assessment of strigolactone GR24 and its derivatives: from anticancer and antidiabetic activities to antioxidant capacity and beyond.
Frontiers in molecular biosciences,
 10, 1242935. https://doi.org/10.3389/fmolb.2023.1242935

 
Ozleyen, A., Cinar, Z. O., Karav, S., Bayraktar, A., Arslan, A., Kayili, H. M., Salih, B., & Tumer, T. B. (2022).
Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols.
Plant foods for human nutrition (Dordrecht, Netherlands),
 77(1), 51–61. https://doi.org/10.1007/s11130-021-00943-2

 
Antika, G., Cinar, Z. Ö., Seçen, E., Özbil, M., Tokay, E., Köçkar, F., Prandi, C., & Tumer, T. B. (2022).
Strigolactone Analogs: Two New Potential Bioactiphores for Glioblastoma.
ACS chemical neuroscience,
 13(5), 572–580. https://doi.org/10.1021/acschemneuro.1c00702

 
Cinar, Z. Ö., Atanassova, M., Tumer, T. B., Caruso, G., Antika, G., Sharma, S., Sharifi-Rad, J., & Pezzani, R. (2021).
Cocoa and cocoa bean shells role in human health: An updated review.
Journal of Food Composition and Analysis,
103, 104115. https://doi.org/10.1016/j.jfca.2021.104115


 
Yildirim, F., Kumrulu, U., Kumrulu, E., Yazar, E., Kuscu, M., Antika, G. & Tumer, T.B. (2021).
Evaluation of BACTECTM FX Blood Culture System for Rapid Sterility Testing of Human Medicinal Solutions for Infusion. 
International Journal of Innovative Approaches in Science Research,
5(1), 1-13. https://doi.org/10.29329/ijiasr.2021.338.1



 Sharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., Kurt, B., Lankatillake, C., Docea, A. O., Moreira, A. C., Dias, D. A., Mahomoodally, M. F., Lobine, D., Cruz-Martins, N., Kumar, M., & Calina, D. (2021).
A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. 
Neurochemical research,
 46(9), 2205–2225. https://doi.org/10.1007/s11064-021-03376-0 

 
Semwal, P., Painuli, S., Painuli, K. M., Antika, G., Tumer, T. B., Thapliyal, A., Setzer, W. N., Martorell, M., Alshehri, M. M., Taheri, Y., Daştan, S. D., Ayatollahi, S. A., Petkoska, A. T., Sharifi-Rad, J., & Cho, W. C. (2021). 
Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns.
Oxidative medicine and cellular longevity,
 2021, 1917890. https://doi.org/10.1155/2021/1917890

 
Taheri, Y., Sharifi-Rad, J., Antika, G., Yılmaz, Y. B., Tumer, T. B., Abuhamdah, S., Chandra, S., Saklani, S., Kılıç, C. S., Sestito, S., Daştan, S. D., Kumar, M., Alshehri, M. M., Rapposelli, S., Cruz-Martins, N., & Cho, W. C. (2021).
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits. 
Oxidative medicine and cellular longevity,
 2021, 1987588. https://doi.org/10.1155/2021/1987588

 
Sharifi-Rad, J., Quispe, C., Rahavian, A., Pereira Carneiro, J. N., Rocha, J. E., Alves Borges Leal, A. L., Bezerra Morais Braga, M. F., Melo Coutinho, H. D., Ansari Djafari, A., Alarcón-Zapata, P., Martorell, M., Antika, G., Tumer, T. B., Cruz-Martins, N., Helon, P., Paprocka, P., Koch, W., Docea, A. O., & Calina, D. (2021).
Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action. 
Frontiers in pharmacology,
 12, 674682. https://doi.org/10.3389/fphar.2021.674682

 
Güngör, T., Ozleyen, A., Yılmaz, Y. B., Siyah, P., Ay, M., Durdağı, S., & Tumer, T. B. (2021).
New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects. 
European journal of medicinal chemistry,
 221, 113566. https://doi.org/10.1016/j.ejmech.2021.113566

 
Sharifi-Rad, M., Berkay Yılmaz, Y., Antika, G., Salehi, B., Tumer, T. B., Kulandaisamy Venil, C., Das, G., Patra, J. K., Karazhan, N., Akram, M., Iqbal, M., Imran, M., Sen, S., Acharya, K., Dey, A., & Sharifi-Rad, J. (2021).
Phytochemical constituents, biological activities, and health-promoting effects of the genus Origanum. 
Phytotherapy research : PTR, 35(1),
95–121. https://doi.org/10.1002/ptr.6785

 

Ozleyen, A., Yilmaz, Y. B., & Tumer, T. B. (2021).
Dataset on the differentiation of THP-1 monocytes to LPS inducible adherent macrophages and their capacity for NO/iNOS signaling.
Data in brief,
 35, 106786. https://doi.org/10.1016/j.dib.2021.106786


Sharifi-Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., Chazot, P. L., Kurt, B., Tumer, T. B., Moreira, A. C., Sharopov, F., Martorell, M., Martins, N., Cho, W. C., Calina, D., & Sharifi-Rad, J. (2020).
Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. 
Journal of clinical medicine,
 9(4), 1061. https://doi.org/10.3390/jcm9041061

 
Kurt, B., Ozleyen, A., Antika, G., Yilmaz, Y. B., & Tumer, T. B. (2020).
Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer's Disease: In Vitro Therapeutic Activities against Neuroinflammation. 
ACS chemical neuroscience,
 11(4), 501–507. https://doi.org/10.1021/acschemneuro.9b00694

 
Kulabas, S. S., Onder, F. C., Yılmaz, Y. B., Ozleyen, A., Durdagi, S., Sahin, K., Ay, M., & Tumer, T. B. (2020).
In vitro and in silico studies of nitrobenzamide derivatives as potential anti-neuroinflammatory agents.Journal of biomolecular structure & dynamics, 38(15), 4655–4668. https://doi.org/10.1080/07391102.2019.1684368
 

Sharifi-Rad, J., Ozleyen, A., Boyunegmez Tumer, T., Oluwaseun Adetunji, C., El Omari, N., Balahbib, A., Taheri, Y., Bouyahya, A., Martorell, M., Martins, N., & Cho, W. C. (2019).
Natural Products and Synthetic Analogs as a Source of Antitumor Drugs. 
Biomolecules,
 9(11), 679. https://doi.org/10.3390/biom9110679

 
Salehi, B., Sharopov, F., Boyunegmez Tumer, T., Ozleyen, A., Rodríguez-Pérez, C., Ezzat, S. M., Azzini, E., Hosseinabadi, T., Butnariu, M., Sarac, I., Bostan, C., Acharya, K., Sen, S., Nur Kasapoglu, K., Daşkaya-Dikmen, C., Özçelik, B., Baghalpour, N., Sharifi-Rad, J., Valere Tsouh Fokou, P., Cho, W. C., … Martins, N. (2019).
Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology. 
Molecules (Basel, Switzerland),
 24(12), 2272. https://doi.org/10.3390/molecules24122272

 
Salehi, B., Tumer, T. B., Ozleyen, A., Peron, G., Dall’Acqua, S., Rajkovic, J., Naz, R., Nosheen, A., Mudau, F. N., Labanca, F., Milella, L., de Tommasi, N., Coutinho, H. D., Sharifi-Rad, J., Verma, D. R., Martorell, M., & Martins, N. (2019).
Plants of the genus Spinacia: From bioactive molecules to food and phytopharmacological applications.
Trends in Food Science & Technology,
88, 260-273. https://doi.org/10.1016/j.tifs.2019.03.028

 
Salehi, B., Zakaria, Z. A., Gyawali, R., Ibrahim, S. A., Rajkovic, J., Shinwari, Z. K., Khan, T., Sharifi-Rad, J., Ozleyen, A., Turkdonmez, E., Valussi, M., Tumer, T. B., Monzote Fidalgo, L., Martorell, M., & Setzer, W. N. (2019). 
Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. 
Molecules (Basel, Switzerland),
 24(7), 1364. https://doi.org/10.3390/molecules24071364


 
Tumer, T. B., Yılmaz, B., Ozleyen, A., Kurt, B., Tok, T. T., Taskin, K. M., & Kulabas, S. S. (2018).
GR24, a synthetic analog of Strigolactones, alleviates inflammation and promotes Nrf2 cytoprotective response: In vitro and in silico evidences. 
Computational biology and chemistry,
 76, 179–190. https://doi.org/10.1016/j.compbiolchem.2018.07.014

 
Kulabas, S. S., Ipek, H., Tufekci, A. R., Arslan, S., Demirtas, I., Ekren, R., Sezerman, U., & Tumer, T. B. (2018).
Ameliorative potential of Lavandula stoechas in metabolic syndrome via multitarget interactions. 
Journal of ethnopharmacology,
 223, 88–98. https://doi.org/10.1016/j.jep.2018.04.043

 
Kapche, D. W. F. G., Lekane, N. M., Kulabas, S. S., Ipek, H., Tok, T. T., Ngadjui, B. T., Demirtas, I., & Tumer, T. B. (2017).
Aryl benzofuran derivatives from the stem bark of Calpocalyx dinklagei attenuate inflammation. 
Phytochemistry,
 141, 70–79. https://doi.org/10.1016/j.phytochem.2017.05.007

 
Tumer, T. B., Onder, F. C., Ipek, H., Gungor, T., Savranoglu, S., Tok, T. T., Celik, A., & Ay, M. (2017).
Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity. 
International immunopharmacology,
 43, 129–139. https://doi.org/10.1016/j.intimp.2016.12.009


Tumer, T. B., Savranoglu, S., Atmaca, P., Terzioglu, G., Sen, A., & Arslan, S. (2016).
Modulatory role of GSTM1 null genotype on the frequency of micronuclei in pesticide-exposed agricultural workers. 
Toxicology and industrial health, 32(12),
1942–1951. https://doi.org/10.1177/0748233715599876


 
Tumer, T. B., Rojas-Silva, P., Poulev, A., Raskin, I., & Waterman, C. (2015).
Direct and indirect antioxidant activity of polyphenol- and isothiocyanate-enriched fractions from Moringa oleifera. 
Journal of agricultural and food chemistry,
 63(5), 1505–1513. https://doi.org/10.1021/jf505014n 

Diana C., Carrie W., TÜMER T., Ilya R., Nava D.
Moringa Leaf Phytochemicals for Skin Benefits Cosmetics and Toiletries
Cosmetics&Toiletries Science Applied ,
 2014 


Savranoglu, S., & Tumer, T. B. (2013).
Inhibitory effects of spirulina platensis on carcinogen-activating cytochrome P450 isozymes and potential for drug interactions. 
International journal of toxicology,
 32(5), 376–384. https://doi.org/10.1177/1091581813503887

 
Tumer, T. B., Sahin, G., & Arinç, E. (2012).
Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia.
Archives of Toxicology,
86(3), 431–439. https://doi.org/10.1007/s00204-011-0760-8

 
Tumer, T. B., Yilmaz, D., Tanrikut, C., Sahin, G., Ulusoy, G., & Arinç, E. (2010).
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. 
Leukemia research,
 34(10), 1275–1281. https://doi.org/10.1016/j.leukres.2010.02.035

 
Tumer, T. B., Ulusoy, G., Adali, O., Sahin, G., Gozdasoglu, S., & Arinç, E. (2007).
The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia. 
American journal of hematology,
 82(10), 906–910. https://doi.org/10.1002/ajh.20947


Ulusoy, G., Adali, O., Tumer, T. B., Sahin, G., Gozdasoglu, S., & Arinç, E. (2007).
Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia. 
Oncology,
 72(1-2), 125–131. https://doi.org/10.1159/000111131

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Terzioğlu Yerleşkesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Araştırma Laboratuvarı (D002),  17100 Çanakkale Merkez/Çanakkale

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